Effects of ethanol exposure in neonatal mice on retinoic acid signaling in forebrain neurons and astrocytes
Mariko Saito, Jungann Park, Anusha Nalluri, Brandon Marino, Colin RO Williams, Donald A Wilson, Bhaskar C Das, John F Smiley · 2026
Read Effects of ethanol exposure in neonatal mice on retinoic acid signaling in forebrain neurons and astrocytes by Mariko Saito, Jungann Park, Anusha Nalluri, Brandon Marino, Colin RO Williams, Donald A Wilson, Bhaskar C Das, John F Smiley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13240825.txt.
Description
Mariko Saito and colleagues publish a 2026 mouse study on alcohol exposure shortly after birth and brain signaling tied to retinoic acid. This vitamin A related signal guides brain development. The newborn mouse stage models the final trimester of human pregnancy, when alcohol can cause lasting harm.
Using reporter mice whose cells glow where the signal is active, the team mapped activity across several brain regions. Activity was strongest in parts of the hippocampus and appeared in certain neuron types and support cells. Alcohol given on day seven reduced signaling in several regions, and it cut signal-carrying inhibitory neurons even more sharply than those cells were lost. The authors suggest weakened signaling may disturb neuron maturation.
Catalog record
| CREATOR | Mariko Saito, Jungann Park, Anusha Nalluri, Brandon Marino, Colin RO Williams, Donald A Wilson, Bhaskar C Das, John F Smiley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |