Activated immune cells present a lung interstitial‐to‐airway/alveolar cross‐compartment sharing pattern in severe pneumonia
Yuean Zhao, Linjing Gong, He Yu, Sifan Zhang, Guanglei Yang, Chaoyang Wang, Weiya Wang, Xuyu Cai, Ye Wang · 2026
Read Activated immune cells present a lung interstitial‐to‐airway/alveolar cross‐compartment sharing pattern in severe pneumonia by Yuean Zhao, Linjing Gong, He Yu, Sifan Zhang, Guanglei Yang, Chaoyang Wang, Weiya Wang, Xuyu Cai, Ye Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13240578.txt.
Description
In severe pneumonia the lung's zones are not sealed off from each other, and immune cells seem to commute between them. Yuean Zhao and co-authors profiled over 275,000 single cells in 2026 from matched lung tissue, airway washings, and blood of twelve patients and five donors. They looked for activated cells shared between the tissue and the air spaces.
One sharing pattern stood out, joining three activated groups: memory-style killer T cells, antibody-making cells, and inflammatory macrophages. The T cells traced back to a blood population that switched on homing markers as it entered the lung, and a shared signal axis linked the macrophages to the other two. The authors offer the pattern as a working hypothesis for treatment research.
Catalog record
| CREATOR | Yuean Zhao, Linjing Gong, He Yu, Sifan Zhang, Guanglei Yang, Chaoyang Wang, Weiya Wang, Xuyu Cai, Ye Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |