Integrative Transcriptomic and Single‐Cell Analyses Identify ATP1A1 as a Prognostic and Immune‐Associated Factor in Esophageal Cancer
Huishen Yan, Liang He · 2026
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Description
Huishen Yan and Liang He single out a cell membrane pump gene as a survival marker in oesophageal cancer in a 2026 analysis. This cancer kills aggressively and lacks good molecular signposts, so the pair mined public tumour data for genes tied to mitochondrial stress that also track patient outcomes.
One gene, ATP1A1, survived the statistical selection and stood alone in predicting better survival when highly expressed. Tumours rich in the gene showed calmer profiles for invasion and spreading programmes, alongside distinctive immune cell mixes. Single-cell data placed the gene mainly in malignant surface cells but also in support and immune cells. Silencing it in laboratory cells changed behaviour and raised inflammatory gene activity.
Catalog record
| CREATOR | Huishen Yan, Liang He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |