Time‐Restricted Feeding Preserves Synaptic Function and Modulates Reelin and α‐Synuclein in an Acute Amyloid‐β Rat Model: A Comparative Study With Alternate‐Day Fasting
Zeynab Maleki, Mohammad Ali Mirshekar, Farzaneh Montazerifar, Bita Etminani, Fateme Keykha · 2026
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Description
Zeynab Maleki and co-authors compare two fasting styles in rats given an Alzheimer-like brain injury in a 2026 study. Eating only within a daily window and fasting every other day are both under study for brain protection, and the team measured memory plus two proteins tied to synapse health and disease.
Rats receiving amyloid injections into the brain performed worse in a water maze, and both fasting regimens improved their scores, with the daily window stronger. Both approaches raised reelin, a protein supporting synapses, and quickened neuron firing. Only the daily window lowered alpha-synuclein, a protein that clumps in several brain diseases. The authors favour time-restricted feeding for follow-up work.
Catalog record
| CREATOR | Zeynab Maleki, Mohammad Ali Mirshekar, Farzaneh Montazerifar, Bita Etminani, Fateme Keykha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |