Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity
Olivia Liseth, Elizabeth Appleton, Benjamin Kendall, Jill Thompson, Thanich Sangsuwannukul, Jason Tonne, Rosa Maria Diaz, Laura Evgin, Anton Patrikeev, Nicolas Sarbia, Shane Foo, Kevin Harrington, Masahiro Ono, Alan Melcher, Richard Vile · 2026
Read Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity by Olivia Liseth, Elizabeth Appleton, Benjamin Kendall, Jill Thompson, Thanich Sangsuwannukul, Jason Tonne, Rosa Maria Diaz, Laura Evgin, Anton Patrikeev, Nicolas Sarbia, Shane Foo, Kevin Harrington, Masahiro Ono, Alan Melcher, Richard Vile (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13240226.txt.
Description
Liseth's team at Mayo Clinic combined CAR T cells with a cancer-killing virus to strengthen treatment of solid tumors. CAR T therapy often falters in solid tumors through fatigue and fading staying power. The team used vesicular stomatitis virus to wake the T cells' own native receptor. That waking happens next to the built-in synthetic receptor.
The pairing produced a subset of virus-primed CAR T cells with stronger killing behavior. Single-cell reads showed these cells grew in clones and switched on effector genes. Their active states and protein profiles differed from unprimed CAR T cells. Helper CD4 T cells proved pivotal in making the primed group, hinting at a new lever for tuning cell therapy.
Catalog record
| CREATOR | Olivia Liseth, Elizabeth Appleton, Benjamin Kendall, Jill Thompson, Thanich Sangsuwannukul, Jason Tonne, Rosa Maria Diaz, Laura Evgin, Anton Patrikeev, Nicolas Sarbia, Shane Foo, Kevin Harrington, Masahiro Ono, Alan Melcher, Richard Vile |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |