Phytochemical Characterization and Neuropharmacological Assessment of Combretum indicum Methanolic Extract With Integrated Molecular Docking and Dynamics Simulation for Anxiety and Depression Therapy
Zobayed Islam, Md. Ashraful Alam, Sakib Ahamed Bhuiyan, Sabikun Naher, Nilufar Sultana, S. M. Naim Uddin · 2026
Read Phytochemical Characterization and Neuropharmacological Assessment of Combretum indicum Methanolic Extract With Integrated Molecular Docking and Dynamics Simulation for Anxiety and Depression Therapy by Zobayed Islam, Md. Ashraful Alam, Sakib Ahamed Bhuiyan, Sabikun Naher, Nilufar Sultana, S. M. Naim Uddin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13240074.txt.
Description
Zobayed Islam and co-authors profile a climbing plant extract as a candidate therapy for anxiety and depression in a 2026 study. Combretum indicum is rich in flavonoids, terpenoids, and alkaloids, classes long tied to calming effects.
Chemical scans confirmed a broad mix of bioactive compounds. In mice, two oral doses of the methanol extract eased anxiety across three standard tests, with more open-arm time and more head dips. It also cut despair-like immobility in swim and suspension tests by about half, rivaling a standard drug. The extract did not sedate the animals. Computer profiling predicted good absorption and brain entry, and docking runs showed strong binding to brain targets. Simulation backed the lead compounds.
Catalog record
| CREATOR | Zobayed Islam, Md. Ashraful Alam, Sakib Ahamed Bhuiyan, Sabikun Naher, Nilufar Sultana, S. M. Naim Uddin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |