Targeting the RNF31–TFEB–NLRP3 Axis With a Curcumin Analog to Restore Autophagy and Alleviate Intestinal Inflammation
Lu Han, Yang Xie, Chunyan Zeng, Youxiang Chen · 2026
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Description
Lu Han and colleagues uncover a chain of events driving bowel inflammation in a 2026 laboratory study. In inflammatory bowel disease the cell-cleaning process called autophagy falters, and the team traced the problem to a tagging enzyme, RNF31, that marks a master switch protein for destruction.
Cell and mouse experiments showed the tagging silences the switch, stalls cleaning, and wakes an inflammatory complex named NLRP3. A synthetic curcumin-like compound called CM-C1 breaks the harmful pairing, restores cleaning flow, and calms inflamed intestines in the mouse model. Gut microbe balance also improved. The authors nominate the compound as a multi-action treatment candidate.
Catalog record
| CREATOR | Lu Han, Yang Xie, Chunyan Zeng, Youxiang Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |