Revisiting ISO 10993‐5 In Vitro Cytotoxicity Standard Tests for Evaluation of Extracellular Matrix‐Based Biomaterials
Rashmi Ramakrishnan, Andrew C. Daly · 2026
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Description
Rashmi Ramakrishnan and Andrew C Daly revisit a standard safety test for medical materials in their 2026 study. The ISO 10993-5 standard guides laboratory checks for whether a material harms cells, with extra weight for products made from extracellular matrix, the natural scaffolding between cells.
The authors ran the recommended assays on commercial matrix products while varying cell type, contact style, and whether serum was present. All tests judged the samples non-toxic, yet metabolic readings swung widely with conditions, reaching well above baseline without matching gains in living cells. Extra stains for cell death and growth gave steadier answers. They propose refining the standard around such direct measures.
Catalog record
| CREATOR | Rashmi Ramakrishnan, Andrew C. Daly |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |