YIF1B Mutational Dysregulation Drives Cutaneous Melanoma Progression by Remodeling the TME
Xiaohan Wang, Yangxu Ding, Wenbo Cai, Chaowei Liu, Huijuan Shi, Hao Chi · 2026
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Description
Xiaohan Wang and colleagues integrated multi-omics data from melanoma cohorts in 2026 to pin down the role of YIF1B, a trafficking protein, in skin cutaneous melanoma. Molecular subtyping by mutation and gene-control features found a worst-prognosis subtype marked by high YIF1B. Laboratory knockdown experiments in two melanoma cell lines tested whether the protein truly drives the aggression.
Silencing YIF1B slowed the cells' movement, invasion, and growth. Mechanistically, high YIF1B blunted the function of tumor-infiltrating killer T cells, and together with an activated IL-6 and JAK signaling loop it fed a cycle of tumor growth plus immune suppression. Genome sequencing showed that loop's activating changes are frequent in aggressive melanoma. The authors propose YIF1B level and pathway status as joint markers for prognosis and treatment guidance.
Catalog record
| CREATOR | Xiaohan Wang, Yangxu Ding, Wenbo Cai, Chaowei Liu, Huijuan Shi, Hao Chi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |