Proteomic Analysis of Corpora Amylacea Extracted From Post‐mortem Brain of MAiD‐end‐of‐life Sporadic ALS Patients
Alexandre Paquet, Lydia Touzel‐Deschênes, Vincent Roy, Stephan Saikali, Nicolas Dupré, François Gros‐Louis · 2026
Read Proteomic Analysis of Corpora Amylacea Extracted From Post‐mortem Brain of MAiD‐end‐of‐life Sporadic ALS Patients by Alexandre Paquet, Lydia Touzel‐Deschênes, Vincent Roy, Stephan Saikali, Nicolas Dupré, François Gros‐Louis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13238840.txt.
Description
Alexandre Paquet, Lydia Touzel-Deschênes, Vincent Roy, Stephan Saikali, Nicolas Dupré, and François Gros-Louis wrote a 2026 paper on starch-like blobs in the brains of people who died with ALS. These blobs, called corpora amylacea, gather with age and in brain diseases. They are often dismissed as waste bins, yet what they hold was poorly known.
The team purified the blobs from donated brains of ALS patients and controls, then read their protein content with mass tools. Nearly four thousand five hundred proteins turned up. The ALS blobs carried a distinct set, including proteins tied to cell scaffolding, failing energy systems, and known ALS markers. The blobs look less like trash and more like records of the disease's damage.
Catalog record
| CREATOR | Alexandre Paquet, Lydia Touzel‐Deschênes, Vincent Roy, Stephan Saikali, Nicolas Dupré, François Gros‐Louis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |