SIRT1: Protean roles at the nexus of health, disease, and therapeutics
Brahim Chaqour · 2026
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Description
Brahim Chaqour reviewed SIRT1 in 2026, portraying the enzyme as a molecular shapeshifter at the crossroads of metabolism, stress defense, and disease. SIRT1 removes chemical tags from proteins using the fuel molecule NAD+, and its targets range from chromosome packaging proteins to the tumor suppressor p53 and the inflammation switch NF-kappa-B. Through them it touches metabolism, daily rhythms, mitochondrial upkeep, immune response, and cell survival.
Activation often protects the heart, blood vessels, and metabolism, yet in cancer the enzyme can suppress tumors in one setting and promote them in another. Its role in longevity stays unresolved across models. Drugs meant to switch it on, resveratrol among them, face problems of specificity and absorption. Chaqour argues that biomarker-guided precision, not blanket activation, is the way forward.
Catalog record
| CREATOR | Brahim Chaqour |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |