Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato · 2026
Read Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition by Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13238704.txt.
Description
Miriam Frosina and colleagues reviewed in 2026 the reach of apolipoprotein E far beyond its famous link to Alzheimer's disease. ApoE ferries fats around the body and brain, and its gene comes in versions that shift disease risk. Evidence from the past decade ties those versions to body fat patterning, bone density, muscle function, and cardiovascular risk, though findings often conflict between studies.
The review follows ApoE through inflammation, glucose and insulin handling, mitochondrial health, cell aging, and controlled cell death. Those pathways sit at the core of many chronic diseases, yet their links to ApoE type remain loosely defined. The authors discuss using ApoE testing to sort risk and personalize prevention. Their closing move reframes ApoE as a whole-body regulator, not a brain-only factor.
Catalog record
| CREATOR | Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 116 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |