Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao · 2026
Read Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles by Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13238688.txt.
Description
Zijie Xiang and a large team reviewed in 2026 how failing mitochondria drive aging-related disease, and what stands in the way of treating them. Mitochondria, the cell's energy plants, falter with age both from internal damage and from breakdowns in the systems that recycle, split, merge, and rebuild them. Escaped mitochondrial DNA can also trigger inflammation through an alarm pathway.
The review connects these failures to muscle, bone, brain, heart, and metabolic diseases. Candidate treatments range from metabolic tuning to transplanting healthy mitochondria and editing mitochondrial DNA directly. Tissue-to-tissue differences in mitochondria remain a major obstacle to clinical use. The authors aim to move mitochondrial medicine from mechanism toward precise intervention.
Catalog record
| CREATOR | Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 140 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |