Deciphering Angiogenic Drivers in Hepatocellular Carcinoma: From Prognostic Signature Construction to Genistein‐Mediated Inhibition
Hao Zheng, Shengwei Tang, Ruida Shi, Zichuan Yu, Ruiyu Zhang, Xiaoyu Qu, Hao Wan, Chenshuo Fang, Xin Wang, Ye Zhu, Da Huang, Gen Chen · 2026
Read Deciphering Angiogenic Drivers in Hepatocellular Carcinoma: From Prognostic Signature Construction to Genistein‐Mediated Inhibition by Hao Zheng, Shengwei Tang, Ruida Shi, Zichuan Yu, Ruiyu Zhang, Xiaoyu Qu, Hao Wan, Chenshuo Fang, Xin Wang, Ye Zhu, Da Huang, Gen Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13238579.txt.
Description
Hao Zheng and eleven co-authors built a prognosis signature for liver cancer and tested a plant compound against it in a 2026 paper. Liver cancer is aggressive and short on reliable markers. Combining network analysis, machine learning, single-cell and spatial data, and docking, the team hunted genes tied to blood vessel growth.
One gene, SCAF1, stood out: raised in tumors, tied to advanced features and worse survival, and concentrated in vessel and immune parts of the tumor scene. Silencing it in cells curbed migration, invasion, and vessel-growth signals. Docking flagged the soy compound genistein as a binder, and lab tests showed it lowered SCAF1 and slowed the cancer cells. The authors propose SCAF1 as both marker and target.
Catalog record
| CREATOR | Hao Zheng, Shengwei Tang, Ruida Shi, Zichuan Yu, Ruiyu Zhang, Xiaoyu Qu, Hao Wan, Chenshuo Fang, Xin Wang, Ye Zhu, Da Huang, Gen Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |