An Epithelial–Mesenchymal Transition–Driven Transcriptional Index Stratifies Immunosuppression and Therapeutic Resistance in Bone Malignancies
Lihe Pang, Ye Hua, Zhaofei Chen, Guoya Wu · 2026
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Description
Lihe Pang and colleagues built a prognostic index in 2026 for bone cancers, drawn from the gene activity program that lets tumor cells change shape and spread, called epithelial-mesenchymal transition. Single-cell and bulk data from several cohorts covered osteosarcoma, Ewing sarcoma, and giant cell tumor of bone. Statistical factorization isolated one transition-driven program inside the malignant cells.
From that program's key genes, survival models distilled an eight-gene bone score. High scores tracked with shorter survival across three independent cohorts, with tumors showing fewer immune cells, weaker checkpoint signals, and predicted resistance to nine chemotherapy drugs. The authors offer the score as a biologically grounded tool for sorting patients by risk. It captures, they argue, the tumor-stroma conversation behind treatment failure.
Catalog record
| CREATOR | Lihe Pang, Ye Hua, Zhaofei Chen, Guoya Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |