Deubiquitinating enzymes in cervical cancer: Molecular mechanisms and therapeutic implications (Review)
Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek · 2026
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Description
Chang-Zhu Pei and co-authors review a family of enzymes that may drive cervical cancer and shape its treatment. Their 2026 review covers deubiquitinating enzymes, which remove ubiquitin tags from proteins and so control whether those proteins survive or are destroyed. Cervical cancer still kills many women worldwide, and tumors often return or resist therapy.
The review explains how these enzymes steady cancer-promoting proteins, weaken tumor suppressors, and tune key signaling pathways. Several are also tied to how tumors respond to radiation and chemotherapy, including in virus-driven cases. That makes them candidate drug targets and markers for choosing treatment. The authors weigh the evidence for bringing enzyme blockers into the clinic. They stress that much of the promise still rests on laboratory work.
Catalog record
| CREATOR | Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |