TPC2 regulates proteomic remodeling, bioenergetic phenotypes, and mitochondrial stress adaptation in melanoma
Homood M. As Sobeai, Ali Hanbashi, Lama Binobaid, Khalid Alhazzani, Sarah M. Almufadhili, Ahmed Altuwaijri, Rashed Almousa, Faroq Kamli, Sulaiman S. Alhudaithi, Moureq Alotaibi, John Parrington · 2026
Read TPC2 regulates proteomic remodeling, bioenergetic phenotypes, and mitochondrial stress adaptation in melanoma by Homood M. As Sobeai, Ali Hanbashi, Lama Binobaid, Khalid Alhazzani, Sarah M. Almufadhili, Ahmed Altuwaijri, Rashed Almousa, Faroq Kamli, Sulaiman S. Alhudaithi, Moureq Alotaibi, John Parrington (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13237393.txt.
Description
As Sobeai and colleagues study a channel protein, TPC2, as a hidden organiser of melanoma's behaviour. Melanoma tumours vary widely, and their conduct is set by tangled signalling, transport, and energy programmes. TPC2 sits in the membranes of the cell's recycling compartments and has been tied to pigmentation, cargo movement, and cancer processes.
The team maps how TPC2 reshapes the cell's protein landscape and energy profile. They also test how it helps melanoma cells adapt when mitochondria, the cell's power plants, come under stress. A channel that coordinates survival under stress could become a drug target, especially in tumours that shrug off current treatments.
Catalog record
| CREATOR | Homood M. As Sobeai, Ali Hanbashi, Lama Binobaid, Khalid Alhazzani, Sarah M. Almufadhili, Ahmed Altuwaijri, Rashed Almousa, Faroq Kamli, Sulaiman S. Alhudaithi, Moureq Alotaibi, John Parrington |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |