A benchmarking framework for comparative evaluation of low-complexity region detection tools in the human proteome
Anirjit Chatterjee, Nagarjun Vijay · 2026
Read A benchmarking framework for comparative evaluation of low-complexity region detection tools in the human proteome by Anirjit Chatterjee, Nagarjun Vijay (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13237088.txt.
Description
Low-complexity regions (LCRs) are compositionally biased segments of proteins that play critical roles in molecular recognition, structural flexibility, and phase separation. Yet, their accurate detection remains challenging due to methodological variability among computational tools. In this study, we conducted a comprehensive benchmarking of eight widely used LCR detection methods (under multiple parameter settings) across the Homo sapiens proteome.
Catalog record
| CREATOR | Anirjit Chatterjee, Nagarjun Vijay |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 108 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |