HBx interacts with the host YBX3 protein and up-regulates its expression to mediate efficient Hepatitis B viral replication
Mel Veen Boo, Jackie Chu, ZiJie Lim, Som Mohanlal Patwa, Wan Jin Hong, Seng Gee Lim, Jayantha Gunaratne, Yee Joo Tan · 2026
Read HBx interacts with the host YBX3 protein and up-regulates its expression to mediate efficient Hepatitis B viral replication by Mel Veen Boo, Jackie Chu, ZiJie Lim, Som Mohanlal Patwa, Wan Jin Hong, Seng Gee Lim, Jayantha Gunaratne, Yee Joo Tan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13237042.txt.
Description
Mel Veen Boo and co-authors identify a host protein that hepatitis B virus needs in a 2026 study. Chronic hepatitis B remains a global burden, and the exact virus-host contacts that sustain it are prime drug targets. A pull-down screen found a new partner for the viral regulator HBx.
The partner, YBX3, binds the regulator's tail end and sits mostly in the nucleus beside it. Knocking the gene out in liver cells crushed viral output, and restoring it revived replication. Infection itself raised YBX3 levels, forming a self-feeding loop. The authors name YBX3 a compelling target for antiviral design.
Catalog record
| CREATOR | Mel Veen Boo, Jackie Chu, ZiJie Lim, Som Mohanlal Patwa, Wan Jin Hong, Seng Gee Lim, Jayantha Gunaratne, Yee Joo Tan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |