Airway epithelial dysfunction in asthma pathogenesis: epigenetic mechanisms, inflammatory crosstalk, and therapeutic opportunities
Bingxue Zhang, Guihua Song, Mengmeng Sun, Yan Zhang, Mingyue Ren · 2026
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Description
Bingxue Zhang and co-authors reviewed in 2026 how the airway lining helps drive asthma, a disease affecting more than 260 million people. Older accounts blamed immune cells alone, yet that view cannot explain why asthma persists, returns during quiet periods, or resists treatment in some patients. The review places damaged airway epithelium at the center.
Barrier leaks let alarm signals escape from the lining, which wakes immune cells and starts type 2 inflammation. Exposures and inflammation also leave lasting chemical marks on the lining cells' DNA packaging, a memory that survives after attacks settle. The authors survey drug ideas aimed at this memory, from enzyme blockers to newer antibody treatments. They note that low-type-2 asthma still needs far more study.
Catalog record
| CREATOR | Bingxue Zhang, Guihua Song, Mengmeng Sun, Yan Zhang, Mingyue Ren |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |