Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes
Montgomery Blencowe, Zara Saleem, Ruoshui Liu, Margaret Wang, I-Hsin Tseng, Julian Wier, Stefan Mutter, Florin Vaida, Yi Guo, Niina Sandholm, Courtney Ackeifi, Daniel L Kaufman, Xia Yang · 2026
Read Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes by Montgomery Blencowe, Zara Saleem, Ruoshui Liu, Margaret Wang, I-Hsin Tseng, Julian Wier, Stefan Mutter, Florin Vaida, Yi Guo, Niina Sandholm, Courtney Ackeifi, Daniel L Kaufman, Xia Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13236778.txt.
Description
Aims/hypothesisAlthough genome-wide association studies (GWAS) have identified loci associated with type 1 diabetes, the specific pathways and regulatory networks linking these loci to disease pathology remain largely unknown. We hypothesised that type 1 diabetes genetic risk factors disrupt tissue-specific biological pathways and gene networks that ultimately lead to beta cell loss.
Catalog record
| CREATOR | Montgomery Blencowe, Zara Saleem, Ruoshui Liu, Margaret Wang, I-Hsin Tseng, Julian Wier, Stefan Mutter, Florin Vaida, Yi Guo, Niina Sandholm, Courtney Ackeifi, Daniel L Kaufman, Xia Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |