Follicular fluid-derived exosomal LINC02701 promotes granulosa cell apoptosis through the GRP75–P53 axis in active endometriosis
Feng Zhou, Xinnan Tang, Kaiquan Li, Nan Lu, Yundong Mao · 2026
Read Follicular fluid-derived exosomal LINC02701 promotes granulosa cell apoptosis through the GRP75–P53 axis in active endometriosis by Feng Zhou, Xinnan Tang, Kaiquan Li, Nan Lu, Yundong Mao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13236687.txt.
Description
Feng Zhou and co-authors traced in 2026 a molecular signal in egg follicle fluid that harms fertility in women with active endometriosis. Tiny vesicles released by cells carry long non-coding RNAs, which regulate gene activity without making proteins. One such RNA stood out as heavily enriched in fluid from patients with active disease. Experiments moved the RNA into granulosa cells, the cells that nourish developing eggs.
Inside those cells, the RNA slowed growth and pushed the cells toward programmed death. Silencing the RNA protected the cells from that fate in the laboratory tests. The RNA binds a helper protein and frees a guardian protein, P53, to enter the nucleus and switch on death genes. Blocking P53 partly reversed the damage caused by the RNA in the experiments. Patients with active disease also showed poorer early embryo quality, matching the cell findings.
Catalog record
| CREATOR | Feng Zhou, Xinnan Tang, Kaiquan Li, Nan Lu, Yundong Mao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |