Glioma-derived extracellular vesicles as drivers of immunotherapeutic resistance: mechanisms of immune reprogramming and metabolic intervention
Jiaxin Wang, Bo Peng, Ting Li, Tianduo Wang · 2026
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Description
Brain tumors of the glioma family fight off immune therapy in part by mailing out tiny packets. Jiaxin Wang and three co-authors review how those packets, called extracellular vesicles, reprogram the immune system in a 2026 paper. The packets carry checkpoint proteins, small RNAs, and fuel-related cargo, and they can cross the blood-brain barrier to act at a distance.
Their checkpoint cargo switches T cells off more broadly than the tumor surface itself. They also swell suppressor cell ranks, tilt macrophages toward helping the tumor, and blunt the cells that present targets. The authors discuss cutting this supply line, including through metabolic intervention.
Catalog record
| CREATOR | Jiaxin Wang, Bo Peng, Ting Li, Tianduo Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |