A two-tier protection strategy for oral delivery of GLP-1 peptides: lipid-based formulation combined with enteric capsules
Camille Dumont, Vanessa Gonzalez, Paula Klatt, Sandrine Picco, Delphine Nombret, Marine Agisson, Euengla Uku, Thibault Saurel, Vincent Jannin · 2026
Read A two-tier protection strategy for oral delivery of GLP-1 peptides: lipid-based formulation combined with enteric capsules by Camille Dumont, Vanessa Gonzalez, Paula Klatt, Sandrine Picco, Delphine Nombret, Marine Agisson, Euengla Uku, Thibault Saurel, Vincent Jannin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13236653.txt.
Description
Camille Dumont and eight colleagues design a two-layer shield to let diabetes peptides be swallowed instead of injected. GLP-1 drugs work well for diabetes and obesity, but the gut breaks them down and absorbs them poorly. Pills would be easier for patients to stick with.
The team paired a model drug, exenatide, with a partner molecule to make it fat-friendly, then packed it into a lipid formula with absorption helpers. The droplets guarded the drug against a key gut enzyme. Sealed inside enteric capsules, the system adds a second wall against stomach acid. Early stability checks showed behavior that depends on the formula. The authors present the pairing as a practical route to oral peptide delivery.
Catalog record
| CREATOR | Camille Dumont, Vanessa Gonzalez, Paula Klatt, Sandrine Picco, Delphine Nombret, Marine Agisson, Euengla Uku, Thibault Saurel, Vincent Jannin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |