Technical evaluation of non-coplanar lattice radiotherapy: achieving directional VPDR uniformity with a 5-mm leaf width multi-leaf collimator

Description

Young Kyu Lee and co-authors evaluated in 2026 a radiotherapy technique that delivers dose in a grid of high peaks and low valleys for bulky tumours. Standard flat delivery showed a strong directional imbalance, with one direction receiving far weaker modulation than the others. Their phantom study built a three-by-three-by-three lattice of dose peaks inside a cylinder. Twenty combinations of peak size and spacing were tested with beams arriving from tilted angles.

Tilted delivery pulled the excessive sideways values down into the range reported by earlier lattice studies. The weak direction rose substantially at the same time, balancing all three directions closely. Healthy tissue overlap with high-dose zones vanished once peak spacing reached modest thresholds for smaller peaks. Beam output stayed evenly spread across the four couch angles used in planning. The authors conclude tilted lattice delivery suits clinical use at practical spacings.

Catalog record

Source: https://europepmc.org/articles/PMC13236622