Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome
Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy Delaney · 2026
Read Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in down syndrome by Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy Delaney (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13236561.txt.
Description
Janelle Posey and a large team study interferon gene dose in Down syndrome lung and platelet troubles. Their study from twenty twenty-six ties one extra gene copy to inflammation. People with Down syndrome face high rates of lung ills. Pulmonary hypertension stands as a grave one of them.
One extra interferon receptor gene lifts immune signals from birth. Platelets may turn that signal into inflammation that harms lung vessels. Blood tests set platelet switch-on in people with the syndrome beside those without it. A mouse model then singled out the interferon path at work. Low oxygen tests showed effects that turned on gene dose in the model. Easing interferon signals might shield lungs in this group.
Catalog record
| CREATOR | Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy Delaney |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |