Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study
Fiyyaz Ahmed-Jushuf, Michael J. Foley, Shayna Chotai, Christopher A. Rajkumar, Danqi Wang, Florentina A. Simader, Krzysztof Macierzanka, Kayla Chiew, Sannidhya Misra, Rupert Williams, Klio Konstantinou, Jehangir N. Din, Shah R. Mohdnazri, Peter D. O’Kane, Peter Haworth, Sukhjinder S. Nijjer, Henry S · 2026
Read Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study by Fiyyaz Ahmed-Jushuf, Michael J. Foley, Shayna Chotai, Christopher A. Rajkumar, Danqi Wang, Florentina A. Simader, Krzysztof Macierzanka, Kayla Chiew, Sannidhya Misra, Rupert Williams, Klio Konstantinou, Jehangir N. Din, Shah R. Mohdnazri, Peter D. O’Kane, Peter Haworth, Sukhjinder S. Nijjer, Henry S (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13236056.txt.
Description
Fiyyaz Ahmed-Jushuf and a large team set out to find the exact blood-flow threshold at which chest pain begins. Their trial protocol and study, ORBITA-FIRE, was published in twenty twenty-six. Stents for stable heart disease aim at symptom relief, yet the pressure measures guiding them were never checked against pain itself.
Patients had stable angina and one narrowed artery. In a double-blind design, pressure ratios were measured at rest and during exercise stress while patients reported pain onset. The goal is to define the flow values where angina truly starts. If the thresholds differ from current cut-offs, stent decisions could be retargeted at the patients who actually gain relief.
Catalog record
| CREATOR | Fiyyaz Ahmed-Jushuf, Michael J. Foley, Shayna Chotai, Christopher A. Rajkumar, Danqi Wang, Florentina A. Simader, Krzysztof Macierzanka, Kayla Chiew, Sannidhya Misra, Rupert Williams, Klio Konstantinou, Jehangir N. Din, Shah R. Mohdnazri, Peter D. O’Kane, Peter Haworth, Sukhjinder S. Nijjer, Henry S |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |