ST-elevation myocardial infarction following de-escalation to aspirin monotherapy: evidence of residual platelet function MRP4 overexpression dependent case report
Vincenzo Cesario, Eleonora Schiera, Mariaignazia Curreli, Giuliano Tocci, Fabio Maria Pulcinelli, Elena Cavarretta, John Kanakakis, Mohamed Elbendary, Símona Chiusolo, Deepti Ranganathan · 2026
Read ST-elevation myocardial infarction following de-escalation to aspirin monotherapy: evidence of residual platelet function MRP4 overexpression dependent case report by Vincenzo Cesario, Eleonora Schiera, Mariaignazia Curreli, Giuliano Tocci, Fabio Maria Pulcinelli, Elena Cavarretta, John Kanakakis, Mohamed Elbendary, Símona Chiusolo, Deepti Ranganathan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13235793.txt.
Description
Vincenzo Cesario and co-authors told the case of a heart attack that struck soon after heart drug cover was stepped down, in a report from twenty twenty-six. Stepping from two anti-clotting drugs to aspirin alone is common after a stent, to cut bleeding risk. But some patients' platelets barely answer to aspirin. The patient was an eighty-two-year-old woman with known coronary disease.
Ten days after the step-down she had a major heart attack, and imaging showed a clot blocking a stented artery. Tests on her platelets found high levels of a protein called MRP4, which is tied to weak aspirin response. She was switched to a stronger drug plan and had no further events in follow-up. The authors suggest testing platelet response, and markers like MRP4, before stepping down cover, so high-risk patients can be spotted in time.
Catalog record
| CREATOR | Vincenzo Cesario, Eleonora Schiera, Mariaignazia Curreli, Giuliano Tocci, Fabio Maria Pulcinelli, Elena Cavarretta, John Kanakakis, Mohamed Elbendary, Símona Chiusolo, Deepti Ranganathan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |