Hydroxytyrosol confers resilience against the depressive, anxiogenic and cognition-disruptive effects of chronic stress
Ariyawan Tantipongpiradet, Reeta Davis, Enrico A. Altieri, Kevin E. O'Connor, Keith J. Murphy · 2026
Read Hydroxytyrosol confers resilience against the depressive, anxiogenic and cognition-disruptive effects of chronic stress by Ariyawan Tantipongpiradet, Reeta Davis, Enrico A. Altieri, Kevin E. O'Connor, Keith J. Murphy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13235406.txt.
Description
Ariyawan Tantipongpiradet and colleagues tested in 2026 whether an olive-derived compound can protect rats against chronic stress. Hydroxytyrosol, produced through biotechnology, was given daily in an oral jelly before and during a period of unpredictable restraint stress. Rats of both sexes underwent tests of anxiety, mood, memory, and social behaviour. Brain tissue from the hippocampus was also sequenced cell by cell.
Stress alone produced anxiety-like behaviour, reduced pleasure response, memory problems, and social withdrawal in the animals. Treatment prevented those behavioural changes across the tests reported. Stress-related drops in dopamine and serotonin were also prevented, while a stress hormone rise was blunted. Thousands of gene changes across neurons and support cells were largely normalized by treatment. The authors identify hydroxytyrosol as a dietary candidate for building stress resilience.
Catalog record
| CREATOR | Ariyawan Tantipongpiradet, Reeta Davis, Enrico A. Altieri, Kevin E. O'Connor, Keith J. Murphy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |