Voluntary wheel running in male mice mitigates select hyperglycemia-induced depressive-like behaviors and modulates BDNF and Tnf in a brain region-specific manner
Laura E Kusumo, Grace A Reese, Matthew J Folh, Jonathan P Duhon, Reece L Bonner, Grace M Read, Caroline G Fowler, Elisabeth G Vichaya · 2026
Read Voluntary wheel running in male mice mitigates select hyperglycemia-induced depressive-like behaviors and modulates BDNF and Tnf in a brain region-specific manner by Laura E Kusumo, Grace A Reese, Matthew J Folh, Jonathan P Duhon, Reece L Bonner, Grace M Read, Caroline G Fowler, Elisabeth G Vichaya (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13235336.txt.
Description
Laura E. Kusumo and co-authors tested in 2026 whether voluntary running eases depression-like behaviour caused by high blood sugar in mice. Diabetes raises depression risk, possibly through brain inflammation and loss of a growth factor called BDNF. Male mice received a chemical that damages insulin production, then lived with or without running wheels for about seven weeks. Behaviour tests and brain tissue measures compared the groups.
High blood sugar produced depression-like behaviour across several tests in the animals. Running improved performance in the forced swim and splash tests specifically. Exercise also raised BDNF expression inside the brain in the results. Other behaviours, including nest building and marble burying, did not respond to running. A marker of inflammation in the cerebellum likewise stayed unchanged with exercise. The authors argue exercise helps a subset of symptoms and suits combined treatment.
Catalog record
| CREATOR | Laura E Kusumo, Grace A Reese, Matthew J Folh, Jonathan P Duhon, Reece L Bonner, Grace M Read, Caroline G Fowler, Elisabeth G Vichaya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |