Unveiling the antioxidant and anti-epileptic potential of Castanea sativa against pentylenetetrazole in mice: a comparative LC-MS analysis of two ethanol-based fractions
Abeer Salama, Rasha M. M. Mohasib, Hagar H. Mourad, Nesrine M. Hegazi, Tarik A. Mohamed, Mohamed-Elamir F. Hegazy · 2026
Read Unveiling the antioxidant and anti-epileptic potential of Castanea sativa against pentylenetetrazole in mice: a comparative LC-MS analysis of two ethanol-based fractions by Abeer Salama, Rasha M. M. Mohasib, Hagar H. Mourad, Nesrine M. Hegazi, Tarik A. Mohamed, Mohamed-Elamir F. Hegazy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234930.txt.
Description
Abeer Salama and co-authors tested in 2026 whether chestnut fruit extracts can calm fits brought on in mice by a stimulant. Epilepsy involves oxidative stress and inflammation in the brain, so plant compounds are studied as add-on options. Fruits were extracted twice, once with weaker ethanol and once with pure ethanol. Lab profiling matched the two fractions before animal testing.
More than seventy compounds appeared, mainly phenolic acids and flavonoids with known protective effects. The pure ethanol fraction held richer chemistry and showed much stronger power in test tube assays. In mice, that fraction delayed fit onset nearly threefold and shortened fits compared with untreated animals. Brain measures moved in a protective direction, with calming signals up and damage markers down. Results came close to those of a standard sedative drug.
Catalog record
| CREATOR | Abeer Salama, Rasha M. M. Mohasib, Hagar H. Mourad, Nesrine M. Hegazi, Tarik A. Mohamed, Mohamed-Elamir F. Hegazy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |