Synthesis and structure–activity relationships of indole-3-butyric acid-based hydrazones: predicting their antibacterial and antioxidant potential through integrated experimental, molecular docking and DFT studies
Mudasara Azam, Talha Mashhood, Shehar Bano, Muhammad Ibrahim, Sehar Nadeem, Humaira Zulfiqar, Nora Hamad Al-Shaalan, Sarah Alharthi, Mohammed A. Amin, Muhammad Usman Khan · 2026
Read Synthesis and structure–activity relationships of indole-3-butyric acid-based hydrazones: predicting their antibacterial and antioxidant potential through integrated experimental, molecular docking and DFT studies by Mudasara Azam, Talha Mashhood, Shehar Bano, Muhammad Ibrahim, Sehar Nadeem, Humaira Zulfiqar, Nora Hamad Al-Shaalan, Sarah Alharthi, Mohammed A. Amin, Muhammad Usman Khan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234927.txt.
Description
Mudasara Azam and co-authors synthesized in 2026 a set of new molecules built from a plant growth compound and tested their biological action. Eight hydrazone versions were made through several steps using different aldehydes or ketones. Standard spectroscopy methods confirmed the structures of the products. Screening covered killing of two bacterial species and scavenging of harmful free radicals.
One version, labelled DHIBH, outperformed the rest on both bacterial tests in the tests. Two other compounds acted selectively against the Gram-positive bacterium at the tested dose. DHIBH also gave the strongest antioxidant result in the radical assay. Computer modelling linked the action patterns to molecular shape, charge distribution, and binding to target proteins. Drug-likeness predictions looked good for the series. The authors argue the scaffold merits further development as a dual-action lead.
Catalog record
| CREATOR | Mudasara Azam, Talha Mashhood, Shehar Bano, Muhammad Ibrahim, Sehar Nadeem, Humaira Zulfiqar, Nora Hamad Al-Shaalan, Sarah Alharthi, Mohammed A. Amin, Muhammad Usman Khan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |