An injectable hyaluronic acid hydrogel integrating Fe(iii)-coordination and polymyxin B grafts for accelerated healing of infected diabetic wounds
Mingchen Zhang, Wei Zhao, Yang Zhou, Ruiting Shen, Yiqiong Sun, Lei Jiang, Jiantao Zhang · 2026
Read An injectable hyaluronic acid hydrogel integrating Fe(iii)-coordination and polymyxin B grafts for accelerated healing of infected diabetic wounds by Mingchen Zhang, Wei Zhao, Yang Zhou, Ruiting Shen, Yiqiong Sun, Lei Jiang, Jiantao Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234830.txt.
Description
Mingchen Zhang and colleagues created in 2026 an injectable gel dressing for infected diabetic wounds, which heal slowly and often become reinfected. The gel starts from hyaluronic acid, a natural skin-related molecule, carrying an attached antibiotic called polymyxin B. Iron ions linked through a helper molecule hold the network together with reversible bonds. Those reversible links let the gel thin under pressure and pass through a needle.
Laboratory tests killed nearly all Escherichia coli bacteria and most Staphylococcus aureus bacteria on contact. The material proved compatible with living tissue in safety checks. In diabetic mice, treated wounds shrank much further by day seven than wounds covered with a commercial dressing. Microscope examination showed better skin regrowth and more collagen laid down in treated wounds. The authors propose the gel for clinical development.
Catalog record
| CREATOR | Mingchen Zhang, Wei Zhao, Yang Zhou, Ruiting Shen, Yiqiong Sun, Lei Jiang, Jiantao Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |