PARP1 trapping activates ATM-mediated NF-κB signaling independent of replication in response to TOP1 blockade
Elodie Bournique, Ambrocio Sanchez, Kim Ha, Katrina M Yan, Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Rémi Buisson · 2026
Read PARP1 trapping activates ATM-mediated NF-κB signaling independent of replication in response to TOP1 blockade by Elodie Bournique, Ambrocio Sanchez, Kim Ha, Katrina M Yan, Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Rémi Buisson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234507.txt.
Description
Elodie Bournique and co-authors uncover a route by which DNA damage switches on inflammation, in a 2026 study. Blocking an enzyme called TOP1 damages DNA and turns on a signal path that drives inflammation. Adding drugs that block a second enzyme, PARP, made that signal far stronger, and the team set out to learn why.
Two routes emerged. One needs DNA copying and follows the collapse of copying forks. The other works without copying and appears when PARP is blocked. The blocking drugs do not just stop the enzyme at work; they trap it on DNA, which blocks repair and sets off the signal through a stress sensor. That trapped state mimics the loss of a repair helper. The authors suggest using such drugs to boost inflammation against cancers treated with TOP1 blockers.
Catalog record
| CREATOR | Elodie Bournique, Ambrocio Sanchez, Kim Ha, Katrina M Yan, Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Rémi Buisson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |