Reduced FBXO22 skews human trophoblast fate equilibrium toward syncytialization via polyubiquitinating the CoREST complex
Hongli Li, Guangmin Song, Linwei Zhou, Man Zhang, Yun Li, Xinmi Liu, Xing Wang, Li Yang, Xinyi Tao, Richard D Cannon, Richard Saffery, Boris Novakovic, Hongbo Qi, Xiaobo Zhou, Hua Zhang · 2026
Read Reduced FBXO22 skews human trophoblast fate equilibrium toward syncytialization via polyubiquitinating the CoREST complex by Hongli Li, Guangmin Song, Linwei Zhou, Man Zhang, Yun Li, Xinmi Liu, Xing Wang, Li Yang, Xinyi Tao, Richard D Cannon, Richard Saffery, Boris Novakovic, Hongbo Qi, Xiaobo Zhou, Hua Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234505.txt.
Description
Hongli Li and co-authors wrote a 2026 paper on how the placenta's cells decide their fate. Early placenta cells can renew themselves or merge into the large surface cells that trade nutrients with the mother's blood. That balance is essential, and when it fails, pregnancies can be lost again and again. The team found a protein, FBXO22, that guards the balance.
The protein was scarce in placentas from patients with repeated pregnancy loss. In lab stem cells, removing it broke their self-renewal and pushed them to merge too early. It works by tagging a partner complex for disposal, which keeps key gene switches set correctly. The finding names a new suspect in unexplained pregnancy loss.
Catalog record
| CREATOR | Hongli Li, Guangmin Song, Linwei Zhou, Man Zhang, Yun Li, Xinmi Liu, Xing Wang, Li Yang, Xinyi Tao, Richard D Cannon, Richard Saffery, Boris Novakovic, Hongbo Qi, Xiaobo Zhou, Hua Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |