Noncanonical chromosomal-end-specific telomeric repeat arrays in naturally telomerase-negative yeasts
Broňa Brejová, Viktória Hodorová, Hana Lichancová, Askar Gafurov, Dominik Bujna, Filip Brázdovič, Filip Červenák, Tomáš Petrík, Eva Hegedűsová, Michaela Forgáčová Jakúbková, Martina Neboháčová, Ľubomír Tomáška, Matthias Sipiczki, Tomáš Vinař, Jozef Nosek · 2026
Read Noncanonical chromosomal-end-specific telomeric repeat arrays in naturally telomerase-negative yeasts by Broňa Brejová, Viktória Hodorová, Hana Lichancová, Askar Gafurov, Dominik Bujna, Filip Brázdovič, Filip Červenák, Tomáš Petrík, Eva Hegedűsová, Michaela Forgáčová Jakúbková, Martina Neboháčová, Ľubomír Tomáška, Matthias Sipiczki, Tomáš Vinař, Jozef Nosek (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234504.txt.
Description
Broňa Brejová and fourteen colleagues report yeasts whose chromosome ends break the textbook pattern. Most species cap their DNA with short repeated tags, TTAGGG style, maintained by the enzyme telomerase. These basidiomycete yeasts lack the telomerase gene entirely, yet their chromosomes end in neat repeat arrays.
Each chromosome end carries its own repeated motif, mostly unique to that end. A shelterin part is also missing, so the upkeep must run on a backup scheme like the alternative lengthening seen in some cancers. The team proposes an ancestor lost telomerase and compensated by amplifying local motifs. The result is a natural experiment in chromosome end survival.
Catalog record
| CREATOR | Broňa Brejová, Viktória Hodorová, Hana Lichancová, Askar Gafurov, Dominik Bujna, Filip Brázdovič, Filip Červenák, Tomáš Petrík, Eva Hegedűsová, Michaela Forgáčová Jakúbková, Martina Neboháčová, Ľubomír Tomáška, Matthias Sipiczki, Tomáš Vinař, Jozef Nosek |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |