Contralateral breast cancer risks for BRCA1, BRCA2, PALB2, CHEK2, and ATM pathogenic variant carriers in two large cohort studies
Isaac Allen, Nancy Whish, Siddhartha Yadav, Nicholas J. Boddicker, Caroline Drukker, Irma van de Beek, Diana M. Eccles, Clare Turnbull, Paul Pharoah, Antonis C. Antoniou, Douglas F. Easton, Fergus J. Couch, Marjanka K. Schmidt, Marc Tischkowitz · 2026
Read Contralateral breast cancer risks for BRCA1, BRCA2, PALB2, CHEK2, and ATM pathogenic variant carriers in two large cohort studies by Isaac Allen, Nancy Whish, Siddhartha Yadav, Nicholas J. Boddicker, Caroline Drukker, Irma van de Beek, Diana M. Eccles, Clare Turnbull, Paul Pharoah, Antonis C. Antoniou, Douglas F. Easton, Fergus J. Couch, Marjanka K. Schmidt, Marc Tischkowitz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234405.txt.
Description
Isaac Allen and a large group of collaborators estimated in 2026 the risk of a second cancer in the opposite breast for women carrying inherited gene variants. They combined data from two large cohort projects on breast cancer genetics. Genes covered were BRCA1, BRCA2, PALB2, CHEK2, and ATM. Dutch population risks helped convert relative effects into ten-year cumulative risks.
Ten-year risks for cancer in the other breast reached roughly ten percent for BRCA1 and BRCA2 carriers. Estimates were lower for the other genes, with ATM carriers near four to five percent. Hazard ratios were clearly raised for BRCA1, BRCA2, and CHEK2 carriers in the pooled analysis. No clear rise appeared for PALB2 or ATM overall, though hormone receptor status of the first cancer changed the picture. The numbers can support counselling about preventive surgery and follow-up.
Catalog record
| CREATOR | Isaac Allen, Nancy Whish, Siddhartha Yadav, Nicholas J. Boddicker, Caroline Drukker, Irma van de Beek, Diana M. Eccles, Clare Turnbull, Paul Pharoah, Antonis C. Antoniou, Douglas F. Easton, Fergus J. Couch, Marjanka K. Schmidt, Marc Tischkowitz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |