Comparison of pharmacovigilance and mechanism analysis of the vascular toxicity caused by platin-based chemotherapy: integration of FAERS analysis, network pharmacology, and endothelial validation
Yuzhu Chen, Chunhua Wang, Peng Jiang, Yida Chen, Tongmei Zhang, Shanshan Cai · 2026
Read Comparison of pharmacovigilance and mechanism analysis of the vascular toxicity caused by platin-based chemotherapy: integration of FAERS analysis, network pharmacology, and endothelial validation by Yuzhu Chen, Chunhua Wang, Peng Jiang, Yida Chen, Tongmei Zhang, Shanshan Cai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234381.txt.
Description
Yuzhu Chen and co-authors examined in 2026 blood vessel harm linked to three platinum chemotherapy drugs used for solid tumours. The drugs were cisplatin, carboplatin, and oxaliplatin. Reports came from a United States safety database covering two decades of adverse event filings. Laboratory work on human vein cells tested how the drugs changed survival and gene activity.
More than ten thousand vascular events were identified across the three medicines. Low blood pressure, flushing, high blood pressure, and clotting were among the most common reports. Network analysis pointed toward pathways involving oxygen sensing, growth signals, and oxidative stress. In cells, oxaliplatin lowered a protective gene called Nrf2 and reduced viability, while cisplatin raised an adhesion gene. The authors advise early heart and vessel monitoring during treatment.
Catalog record
| CREATOR | Yuzhu Chen, Chunhua Wang, Peng Jiang, Yida Chen, Tongmei Zhang, Shanshan Cai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |