Rational design of a modular mRNA vaccine platform for rapid adaptation to SARS-CoV-2 variants
Julia Rudert, Julia Volckmar, Andreas Jeron, Maike Bälkner, Pia Grimpe, Henning Jacobsen, Dandan Zhang, Giovana Bavia Bampi, Luka Cicin-Sain, Dunja Bruder, Joseph Rosenecker, Xiaoyan Ding · 2026
Read Rational design of a modular mRNA vaccine platform for rapid adaptation to SARS-CoV-2 variants by Julia Rudert, Julia Volckmar, Andreas Jeron, Maike Bälkner, Pia Grimpe, Henning Jacobsen, Dandan Zhang, Giovana Bavia Bampi, Luka Cicin-Sain, Dunja Bruder, Joseph Rosenecker, Xiaoyan Ding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234338.txt.
Description
Julia Rudert and colleagues described in 2026 a flexible messenger RNA vaccine platform aimed at changing coronavirus variants. As SARS-CoV-2 evolves, older vaccines lose strength against new forms of the spike protein. The team built and compared three optimized candidates in mice during a prime and boost schedule. Each candidate carried instructions for parts of the virus that bind to human cells.
One candidate, called TP2A, covered the original virus plus the Delta and Omicron variants and performed best. It produced an early antibody response dominated by one antibody type and activity across variants. It also raised virus-specific T cells, including killer T cells, in spleen and nearby lymph nodes. Because its parts can be swapped, the platform could be adapted quickly to future variants or other viruses.
Catalog record
| CREATOR | Julia Rudert, Julia Volckmar, Andreas Jeron, Maike Bälkner, Pia Grimpe, Henning Jacobsen, Dandan Zhang, Giovana Bavia Bampi, Luka Cicin-Sain, Dunja Bruder, Joseph Rosenecker, Xiaoyan Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |