Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer
Xiuping Guo, Wensheng Zheng, Kaichao Song, Tingting Zhang, Zhigang Luo, Zhouguang Hui, Qingbo Chen, Yuting Qin, Yanan Sun, Chujuan Hu, Xiaolian Tian, Sitong Yang, Ling Ren, Quanyong Yu, Haoyang Yu, Bozhao Li, Yingying He, Yuanbin Li, Mingyu Pan, Yongsheng Che, Guangjun Nie, Jiandong Jiang, Lulu Wang · 2026
Read Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer by Xiuping Guo, Wensheng Zheng, Kaichao Song, Tingting Zhang, Zhigang Luo, Zhouguang Hui, Qingbo Chen, Yuting Qin, Yanan Sun, Chujuan Hu, Xiaolian Tian, Sitong Yang, Ling Ren, Quanyong Yu, Haoyang Yu, Bozhao Li, Yingying He, Yuanbin Li, Mingyu Pan, Yongsheng Che, Guangjun Nie, Jiandong Jiang, Lulu Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234315.txt.
Description
Xiuping Guo and a large team reported in 2026 on a timed nanomedicine for triple-negative breast cancer, a hard-to-treat form of the disease. Chemotherapy can kill cancer cells in a way that alerts the immune system. Yet the same treatment triggers a suppressive signal called prostaglandin E2, which blunts that alert. Their tiny vesicle was designed to release its two drugs in sequence inside tumours.
First, celecoxib is freed quickly to lower the suppressive signal in nearby tissue. Later, a linked form of gemcitabine becomes active and kills cells in a more immune-stimulating way. In tumour models, the sequence raised dendritic cell maturity, strengthened anti-tumour immunity, and slowed growth and spread. The work offers a timing-based strategy for other cancers that resist immune attack.
Catalog record
| CREATOR | Xiuping Guo, Wensheng Zheng, Kaichao Song, Tingting Zhang, Zhigang Luo, Zhouguang Hui, Qingbo Chen, Yuting Qin, Yanan Sun, Chujuan Hu, Xiaolian Tian, Sitong Yang, Ling Ren, Quanyong Yu, Haoyang Yu, Bozhao Li, Yingying He, Yuanbin Li, Mingyu Pan, Yongsheng Che, Guangjun Nie, Jiandong Jiang, Lulu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |