Vertebral BMSC-EVs under estrogen deficiency drive senescence-related mitochondrial dysfunction in endplate chondrocytes via MRPL1 mRNA delivery
Yiming Zhong, Zhuoxin Li, Haofeng Hong, Zhenda Zhao, Longting Chen, Zihuan Yang, Dongwei Fan, Wanqiong Yuan, Da Zou, Hua Tian, Chunli Song, Weishi Li, Huijie Leng · 2026
Read Vertebral BMSC-EVs under estrogen deficiency drive senescence-related mitochondrial dysfunction in endplate chondrocytes via MRPL1 mRNA delivery by Yiming Zhong, Zhuoxin Li, Haofeng Hong, Zhenda Zhao, Longting Chen, Zihuan Yang, Dongwei Fan, Wanqiong Yuan, Da Zou, Hua Tian, Chunli Song, Weishi Li, Huijie Leng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234282.txt.
Description
Yiming Zhong and co-authors trace a chain by which estrogen loss after menopause speeds spinal degeneration. The weak point is the cartilage endplate of the vertebra, where lumbar decline begins. The team shows that estrogen deficiency ages the bone marrow stem cells of the spine. Those aged cells shed tiny vesicles loaded with a message for MRPL1, a gene for a mitochondrial protein-building part.
Neighbor cartilage cells take up the vesicles and read the message. Extra MRPL1 tangles with a core energy enzyme and hobbles it, leaving the cells with senescence-linked mitochondrial failure. The common drug doxycycline damped the message and the mitochondrial overdrive, and it eased endplate decay in rats lacking estrogen. The authors present the pathway as a new drug target in postmenopausal back disease.
Catalog record
| CREATOR | Yiming Zhong, Zhuoxin Li, Haofeng Hong, Zhenda Zhao, Longting Chen, Zihuan Yang, Dongwei Fan, Wanqiong Yuan, Da Zou, Hua Tian, Chunli Song, Weishi Li, Huijie Leng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |