Changes in palmitate- and stearate-containing glycerophospholipids in skeletal muscle during clenbuterol-induced fast-twitch fiber transition and hypertrophy
Yuna Suzuki, Tomoki Sato, Satoshi Ohuchi, Sango Nakashima, Noriyuki Miyoshi, Shinji Miura · 2026
Read Changes in palmitate- and stearate-containing glycerophospholipids in skeletal muscle during clenbuterol-induced fast-twitch fiber transition and hypertrophy by Yuna Suzuki, Tomoki Sato, Satoshi Ohuchi, Sango Nakashima, Noriyuki Miyoshi, Shinji Miura (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13234236.txt.
Description
Yuna Suzuki and colleagues published a 2026 muscle lipid study on how membrane fats remodel when muscle shifts toward fast-twitch fibers. Fast and slow fibers carry distinct glycerophospholipid recipes, and slow shifts were known to rewrite them. The team used clenbuterol, a drug that drives fast-twitch conversion and growth, in mice and profiled the fats in two leg muscles.
Treated muscle gained fast-twitch share and bulked up. Its membranes held more of a palmitate-bearing phosphatidylcholine and less of the stearate-bearing version, in both muscles studied. Genes for the enzymes that choose which fatty chain gets attached changed in step, including one called GPAT3. The authors conclude that lipid remodeling is a genuine part of how muscle retools its identity, not a bystander effect.
Catalog record
| CREATOR | Yuna Suzuki, Tomoki Sato, Satoshi Ohuchi, Sango Nakashima, Noriyuki Miyoshi, Shinji Miura |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |