Epidermal MHC-II-mediated NK cell recruitment triggers keratinocyte pyroptosis, facilitating pathogenesis of psoriasis
Xiaoqing Yi, Pian Yu, Jiayi Wang, Chi Fang, Sihui Ma, Kaixuan Li, Rongxuan Yan, Guanming Wang, Yihui Chen, Chao Chen, Detian Zhang, Yehong Kuang, Wu Zhu, Jie Li, Guoqiang Zhang, Tuo Deng, Xiang Chen, Cong Peng · 2026
Read Epidermal MHC-II-mediated NK cell recruitment triggers keratinocyte pyroptosis, facilitating pathogenesis of psoriasis by Xiaoqing Yi, Pian Yu, Jiayi Wang, Chi Fang, Sihui Ma, Kaixuan Li, Rongxuan Yan, Guanming Wang, Yihui Chen, Chao Chen, Detian Zhang, Yehong Kuang, Wu Zhu, Jie Li, Guoqiang Zhang, Tuo Deng, Xiang Chen, Cong Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233949.txt.
Description
Xiaoqing Yi leads a large team on skin cell signals in psoriasis. Their study from twenty twenty-six deals with keratinocyte and immune cell interplay. Psoriasis is a chronic skin swelling disease.
Natural killer cells were far more common in lesions. Skin cells used a class II signal to draw them in. Blocking that signal cut disease in model mice. A chemokine path carried the recruitment signal inside cells. Spatial gene maps showed the two cell types side by side. Killer cells released a granule enzyme that burst skin cells. Removing either partner eased the skin disease.
Catalog record
| CREATOR | Xiaoqing Yi, Pian Yu, Jiayi Wang, Chi Fang, Sihui Ma, Kaixuan Li, Rongxuan Yan, Guanming Wang, Yihui Chen, Chao Chen, Detian Zhang, Yehong Kuang, Wu Zhu, Jie Li, Guoqiang Zhang, Tuo Deng, Xiang Chen, Cong Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |