Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes
Lucas Maurin, Lorella Marselli, Mathilde Boissel, Vincent Pascat, Mara Suleiman, Emma Henriques, Carmela De Luca, Lijiao Ning, Marie Fourcot, Marta Tesi, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Frédérik Oger, Frederic Burdet, Mickael Canouil, Miriam Cnop, Mark Ibberson, Amélie B · 2026
Read Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes by Lucas Maurin, Lorella Marselli, Mathilde Boissel, Vincent Pascat, Mara Suleiman, Emma Henriques, Carmela De Luca, Lijiao Ning, Marie Fourcot, Marta Tesi, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Frédérik Oger, Frederic Burdet, Mickael Canouil, Miriam Cnop, Mark Ibberson, Amélie B (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233915.txt.
Description
Lucas Maurin and colleagues published a 2026 epigenetics study separating the marks that ageing leaves on pancreatic islets from those left by type 2 diabetes. Islets house the insulin-making beta cells, and age is diabetes' strongest risk factor, so the two influences tangle easily. The team combined DNA methylation, gene activity, and genetic data from 144 islet donors.
Age-linked and diabetes-linked chemical marks barely overlapped. Age marks clustered in gene promoters and formed coordinated programs tied to insulin secretion, while diabetes marks sat in enhancer regions and looked like scattered stress damage. Genetic analysis supported a causal role for one age-linked mark regulating a known diabetes gene. A blood test score built from age marks tracked insulin secretion and sharpened diabetes classification when paired with genetic risk.
Catalog record
| CREATOR | Lucas Maurin, Lorella Marselli, Mathilde Boissel, Vincent Pascat, Mara Suleiman, Emma Henriques, Carmela De Luca, Lijiao Ning, Marie Fourcot, Marta Tesi, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Frédérik Oger, Frederic Burdet, Mickael Canouil, Miriam Cnop, Mark Ibberson, Amélie B |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |