Mechanisms of breast cancer dormancy in bone metastasis
Maria L. Price, Jiabao Zhou, Christine L. Le Maitre, Lewis A. Quayle, Penelope D. Ottewell · 2026
Read Mechanisms of breast cancer dormancy in bone metastasis by Maria L. Price, Jiabao Zhou, Christine L. Le Maitre, Lewis A. Quayle, Penelope D. Ottewell (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233890.txt.
Description
Maria L. Price and colleagues published a 2026 review on breast cancer cells that hide dormant in bone for years before waking to form metastases. Bone marrow shelters these sleepers well, and their stem-like traits shrug off standard therapies. Because dormant cells are nearly impossible to spot in patients, the mechanisms holding them asleep remain only partly mapped.
The review walks through what regulates dormancy in bone, from signals in the marrow niche to the cancer cells' own survival programs. It then surveys traditional and state-of-the-art methods for studying dormant cells, including models built to watch them over long periods. The authors argue that understanding the sleep switch is the route to treatments that either keep cells dormant forever or flush them out for killing.
Catalog record
| CREATOR | Maria L. Price, Jiabao Zhou, Christine L. Le Maitre, Lewis A. Quayle, Penelope D. Ottewell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |