Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain
Emanuel D. Peralta, Yanaysis Stable García, Santiago V. Soria, Sergio G. Benitez, Cristian G. Acosta · 2026
Read Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain by Emanuel D. Peralta, Yanaysis Stable García, Santiago V. Soria, Sergio G. Benitez, Cristian G. Acosta (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233714.txt.
Description
Emanuel Peralta and co-authors (2026) studied how blood-pressure hormone receptors shape a potassium channel tied to nerve pain. The channel, called TWIK1, sits in sensory neurons. Rats with a squeezed sciatic nerve, a standard model of neuropathic pain, showed less TWIK1 in their nerve ganglia. The team gave the rats blockers of the two angiotensin receptors, alone and together, for fourteen days. They tracked channel levels, pain behavior, blood inflammation markers, and glial activity.
Blocking both receptors worked best. It restored or raised channel levels, eased responses to touch and cold, and lowered circulating inflammatory signals. The support cells around neurons also calmed. In dish tests, inflammation alone cut the channel's message, matching the animal picture. The authors conclude the two receptors jointly tune the channel through inflammation and glia. They propose tuning this hormone system as a candidate route to new pain treatments.
Catalog record
| CREATOR | Emanuel D. Peralta, Yanaysis Stable García, Santiago V. Soria, Sergio G. Benitez, Cristian G. Acosta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |