ITGA5 is overexpressed and promotes tumor progression through SNAI2 in OSCC
Yanan Li, Li Kong, Kai Zhou, Jinfei Gu, Liping Sun, Shuxin Ding, Bo Zou, Dongping Zhang, Zhen Meng · 2026
Read ITGA5 is overexpressed and promotes tumor progression through SNAI2 in OSCC by Yanan Li, Li Kong, Kai Zhou, Jinfei Gu, Liping Sun, Shuxin Ding, Bo Zou, Dongping Zhang, Zhen Meng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233712.txt.
Description
Oral cancer of the mouth lining is deadly and often found late. Yanan Li and co-authors studied a cell surface protein called ITGA5, which is switched on at high levels in head and neck cancers. Using public databases, they showed the protein is overproduced in these tumors at both the gene and protein level, and that high levels track with poorer survival. They then tested what the protein does in oral cancer cells in the lab.
Turning ITGA5 down slowed the cancer cells' growth, invasion, and movement, and reversed a shape shifting program they use to spread. Turning up a second factor, SNAI2, undid those effects, which places SNAI2 downstream of ITGA5 in the chain of command. The authors conclude that ITGA5 drives oral cancer progression through SNAI2. They propose the protein as both a warning marker and a possible drug target for this cancer.
Catalog record
| CREATOR | Yanan Li, Li Kong, Kai Zhou, Jinfei Gu, Liping Sun, Shuxin Ding, Bo Zou, Dongping Zhang, Zhen Meng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |