A cell death program–based tumor signature stratifies prognosis, immune landscape, and therapeutic response in glioma
Huaichao Zhang, Zijiang Yang, Qiang Xie, Pin Chen, Jinlong Huang, Shuang Liu, Zeyang Li, Wei Sun, Xiaobiao Zhang, Tao Xie · 2026
Read A cell death program–based tumor signature stratifies prognosis, immune landscape, and therapeutic response in glioma by Huaichao Zhang, Zijiang Yang, Qiang Xie, Pin Chen, Jinlong Huang, Shuang Liu, Zeyang Li, Wei Sun, Xiaobiao Zhang, Tao Xie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233278.txt.
Description
Gliomas, tumors of the brain's support cells, vary enormously in how they behave. Huaichao Zhang and co-authors build a risk score from genes tied to two ways cells die: quiet self-destruction and fiery bursting. They fit the score on a large public cancer dataset and check it on outside groups. The score splits patients into high-risk and low-risk groups with clearly different survival.
High-risk tumors carried more mutations and showed busier cell-division and inflammation signals. Single-cell data placed the risky pattern in aggressive tumor cell states that talk heavily to immune and support cells. Those tumors drew in many immune cells yet showed signs the immune attack was worn out. In dish tests, chemotherapy triggered both death styles at once. The authors propose the score as a guide for prognosis and treatment choices.
Catalog record
| CREATOR | Huaichao Zhang, Zijiang Yang, Qiang Xie, Pin Chen, Jinlong Huang, Shuang Liu, Zeyang Li, Wei Sun, Xiaobiao Zhang, Tao Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |