Growth hormone-secreting adenoma with lack of retinoblastoma protein expression
Roberto Salvatori, Gary L Gallia, Calixto-Hope G Lucas · 2026
Read Growth hormone-secreting adenoma with lack of retinoblastoma protein expression by Roberto Salvatori, Gary L Gallia, Calixto-Hope G Lucas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13233132.txt.
Description
Roberto Salvatori, Gary L Gallia, and Calixto-Hope G Lucas published a 2026 case report linking a missing tumor suppressor protein to a growth hormone tumor. The retinoblastoma protein normally brakes cell growth, and mice lacking its gene reliably develop pituitary tumors. Whether the same holds in people has been unclear.
Their patient developed eye cancer at age one from an inherited RB1 gene variant and was diagnosed at twenty with a somatotropinoma, a pituitary tumor that releases growth hormone. Staining of the tumor showed its cells had lost the retinoblastoma protein entirely. The case suggests the protein also guards the human pituitary, and it gives doctors a reason to watch RB1 carriers for pituitary growths.
Catalog record
| CREATOR | Roberto Salvatori, Gary L Gallia, Calixto-Hope G Lucas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |