The association between CD40 gene polymorphisms and the risk of cancer based on a meta-analysis
Sixin Li, Xichen Feng, Anjie Chen, Jiandong Gui, Chenwei Gu, Chen Guo, Yujie Deng, Yuanyuan Mi · 2026
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Description
Sixin Li and co-authors pool studies on whether variants in the CD40 gene change cancer risk in a 2026 analysis. CD40 is an immune receptor that shapes tumor growth, cell death, and anti tumor immunity, and its levels vary by cancer type. Single studies on its gene variants gave mixed answers.
The team searched five databases to February 2025 and kept 10 high quality papers holding 20 case control studies. They compared several genetic models and split results by subgroups. They also mined public data on CD40 levels in tumors versus normal tissue, on survival links, and on variant spread across six world populations, plus a network of its protein partners.
Catalog record
| CREATOR | Sixin Li, Xichen Feng, Anjie Chen, Jiandong Gui, Chenwei Gu, Chen Guo, Yujie Deng, Yuanyuan Mi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |